ABSTRACT
Objective:To compare the clinical efficacy and safety between spleen total resection splenectomy and spleen partial splenectomy in the treatment of patients with traumatic spleen rupture.Methods:84 cases of patients with traumatic spleen rupture from March 2013 to March 2016 were selected and divided into two groups.42 cases in the spleen total resection group were treated with spleen total resection,while the other 42 cases in the spleen partial nephrectomy group were treated with spleen partial splenectomy.The operative effect,the levels of platelet count,serum IgA,IgG,IgM,CD3 +,CD4 +,CD8 +,CD4 + / CD8 + levels before and after treatment,the incidence of complications were compared between two groups.Results:The intraoperative blood loss,exhaust time,length of hospital stay of spleen partial nephrectomy group were shorter than those of the spleen total resection group,but the operation time of research group was longer than that of the spleen total resection group (P＜0.05).The platelet count,CD8+ of spleen partial nephrectomy group were lower than those of the spleen total resection group (P＜0.05).The IgA,IgG,IgM,CD3+,CD4+,CD8+,CD4+/CD8+ of spleen partial nephrectomy group were significantly higher than those of the spleen total resection group (P＜0.05).The incidence rate of complications in the spleen partial nephrectomy group was lower than that of the spleen total resection group (P＜0.05).Conclusion:Spleen partial splenectomy was more effective than spleen total resection in the treatment of traumatic splenic rupture,which had little effect on the platelet and immune function.
ABSTRACT
Gene analysis of the first family with ?-thalassemia in Xinjiang was carried out by polymerase chain reaction (PCR) in combination with dot blot hybridization of allele -specific oligonucleotide (ASO) probes. Seven of the 12 family members were heterozygous for the IVS- Ⅱ-654 (C→T) mutation. The abnormal ? gene of proband was confirmed from the paternal side according to family survey, clinical syndrome and hematological data.
ABSTRACT
This paper presents the results of a mass survey for abnormal hemoglobins in Xinjiang. 117, 847 sub-jects of 21 nationalities in 31 countries (cities) were examined. Seven hundred and ten instances of abnormal hemoglobins .and thalassemias were identified. Hematological and biochemical investigations as well as clinical and family studies were carried out on 52 prebands. The overall incidence of abnormal hemo- globing was 4.23%. Altogether 17 abnormal hemoglo-bins were detected in 8 out of 21 different nationali-ties with their incidences ranging from 0.21 to 12.8%.They were mainly of the D group, which accounted for 61.3% of the total. The above results indicated that Xinjiang is one of the regions where high incid-ence of abnormal hemoglobins occurs in China with certain ethnic and geographical peculiarities. Types,distributions, clinical and genetic features of these abnormal hemoglobins were briefly discussed.